The McDonald Lab

Cell migration in development and disease

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Kristen receiving her certificate from the graduate college

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Latest lab news:

New paper: A deficiency screen of the X chromosome for Rap1 GTPase dominant interacting genes in Drosophila border cell migration. Messer CL, Burghardt E, McDonald JA. G3 (Bethesda). 2025 May 8;15(5):jkaf040. doi: 10.1093/g3journal/jkaf040.PMID: 39993182

Our paper was featured in a commentary: Cell migration: Collective cell migration is intrinsically stressful. Wang H, Chen J.Curr Biol. 2024 Apr 8;34(7):R275-R278. doi: 10.1016/j.cub.2024.02.061. PMID: 38593770

New paper: Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response. Chen Y, McDonald JA.Curr Biol. 2024 Apr 8;34(7):1390-1402.e4. doi: 10.1016/j.cub.2024.02.014. Epub 2024 Feb 29.PMID: 38428416

Recent paper: Burghardt E, Rakijas J, Tyagi A, Majumder P, Olson BJSC, McDonald JA. Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration. BMC Genomics. 2023 Dec 1;24(1):728. doi: 10.1186/s12864-023-09839-8. PMID: 38041052

Jocelyn gave a talk in the excellent Cell Migration Seminar series. You can see it here on YouTube.

Papers we are reading:

Chemotaxis of Drosophila border cells is modulated by tissue geometry through dispersion of chemoattractants. George A, Akhavan N, Peercy BE, Starz-Gaiano M. iScience. 2025 Feb 5;28(3):111959. doi: 10.1016/j.isci.2025.111959. eCollection 2025 Mar 21.PMID: 40060906

Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs. Ghosh G, Das D, Nandi A, De S, Gangappa SN, Prasad M. J Cell Biol. 2025 Aug 4;224(8):e202411073. doi: 10.1083/jcb.202411073. Epub 2025 May 28.PMID: 40434296

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