Cell migration in development and disease
We use Drosophila border cells to study how groups of cells move in the three-dimensional environment of tissues. We are interested in how cells migrate during development, e.g. during organ formation and tissue remodeling, and in diseases such as cancer, where it contributes to tumor invasion and metastasis.
We use a combination of live imaging, genetics, and cell biological approaches to uncover how multicellular collective cell migration is controlled. We primarily use the fruit fly “border cell” model but also address the role of collective cell movement in human cancer, such as glioblastoma (collaboration with the lab of Justin Lathia, Cleveland Clinic).
Our current interests:
- How do collectives maintain their shape and ability to move within confined tissues?
- How do single cells come together and communicate to produce group movement?
- How do cells stay together while migrating as collectives?
- How do cells break away from epithelia to become migratory?
- Interplay of polarity and cytoskeletal regulatory proteins in collective cell migration
- Application of Drosophila border cell model to tumor invasion
The McDonald lab is located at Kansas State University in the Division of Biology – Manhattan, KS